Belly or duodenal ulcer. Should you have a tummy ulcer or duodenal ulcer, prednisone could make it worse. Taking prednisone with an NSAID (ache reliever) which include ibuprofen may also improve your possibility of creating or worsening an ulcer. When you've got 1 of such ulcers, talk to your doctor about irrespective of whether prednisone is right